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Active Ingredients

Chartoreg Co® Bilayer Tablets

• 10/40 mg
• 5/80 mg
• 10/80 mg
  (Amlodipine / Telmisartan)

Indications and Usage

Chartoreg Co® (amlodipine/telmisartan) tablets are indicated for the treatment of hypertension, either:

• As monotherapy, or
• In combination with other antihypertensive agents,
  to effectively lower blood pressure.

Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events, particularly:

• Stroke
• Myocardial infarction

These benefits have been demonstrated in controlled clinical trials involving antihypertensive drugs from multiple pharmacological classes, including:

• Angiotensin II receptor blockers (ARBs)
• Dihydropyridine calcium channel blockers (CCBs)

Clinical Benefits of Blood Pressure Control

• Blood pressure reduction itself—rather than other drug-specific effects—is primarily responsible for cardiovascular risk reduction.
• The most consistent benefit observed is a reduced risk of stroke, with additional reductions in:
  • Myocardial infarction
  • Cardiovascular mortality
• Even modest reductions in severe hypertension can provide substantial clinical benefit.
• Relative risk reduction is similar across populations, but absolute benefit is greater in high-risk patients, such as those with:
  • Diabetes
  • Hyperlipidemia

Comprehensive Cardiovascular Risk Management

Blood pressure control should be part of a broader risk-reduction strategy that may include:

• Lipid management
• Diabetes control
• Antithrombotic therapy
• Smoking cessation
• Regular exercise
• Reduced sodium intake

Many patients will require more than one antihypertensive drug to achieve target blood pressure goals.

Special Considerations

• Some antihypertensive drugs may have reduced efficacy as monotherapy in certain populations (e.g., Black patients).
• Many agents also have additional indications, such as:
  • Angina
  • Heart failure
  • Diabetic kidney disease
    These factors may influence therapy selection.

Initial Therapy Use

Chartoreg Co® tablets may be used as initial therapy in patients who are likely to require multiple agents to achieve blood pressure control.

When selecting Chartoreg Co® as initial therapy, consider:

• Baseline blood pressure
• Target blood pressure goals
• Patient risk profile
• Likelihood of achieving control with combination therapy versus monotherapy
• Patient tolerance of the starting dose

Patients with moderate to severe hypertension are at increased risk of:

• Cardiovascular events
• Kidney failure
• Vision impairment